CFIBCR @ PMCC, UHN
Director of the Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre; University Professor, Departments of Medical Biophysics and Immunology, University of Toronto and University of Hong Kong.
Dr. Mak received his B.Sc. and M.Sc. degrees from the University of Wisconsin (Madison) and his Ph.D. degree from the University of Alberta. His postdoctoral work was performed at the Ontario Cancer Institute under the supervision of Dr. Ernest McCulloch.
Dr. Mak’s research interests center on immune cell recognition/regulation, molecular mechanisms underlying the survival and death of normal or malignant cells, as well as the role of inflammation in the progression of autoimmune disease and cancer. He is best known as the lead scientist of the group that first cloned the genes of the human T cell antigen receptor, a discovery that provided essential insights into the molecular basis of cellular immunity. In addition, Dr. Mak has devoted a large portion of his research to investigating the pathogenesis of cancer. In particular, he is interested in mechanisms of metabolic transformation in order to identify potential targets for novel cancer therapeutics.
Dr. Mak has published over 900 peer-reviewed research papers and holds many patents. His many accomplishments have been recognized by the scientific community through numerous prestigious awards and honours, such as the, Emil von Behring Prize, Gairdner International Award, King Faisal International Prize for Medicine, Sloan Prize, and Novartis Immunology Prize. He is a Fellow of the Royal Society of London, a Foreign Associate of the National Academy of Sciences (USA), an Officer of the Orders of Ontario and Canada and a Fellow of American Association for Cancer Research Academy (USA).