Trude Helen Flo
Norwegian University of Science and Technology
My research ambition is to reveal novel host defense mechanisms to mycobacterial and HIV pathogens and virulence strategies employed by mycobacteria and HIV to parasitize host cells. We have a BSL3 lab with a Leica SP8 confocal microscope where we investigate host-pathogen relations in M. tuberculosis infected macrophages and HIV infection of T cells and we have established methods for correlative imaging at an ultra-high resolution and in 3D using FIB-SEM together with fluorescence microscopy. Intracellular trafficking and compartmentalized receptor signaling are central for survival and attractive targets for drug development and are currently investigated in our lab both in the host and in the pathogens.