The University of Texas MD Anderson Cancer Center
Dr. Shao-Cong Sun is a professor and Deputy Chair in the Department of Immunology and holder of the Moshe Talpaz Endowed Chair in Immunology at The University of Texas MD Anderson Cancer Center. He received PhD degree from Stockholm University and pursued postdoctoral training with Dr. Warner Greene at The Gladstone Institute of Virology and Immunology, University of California at San Francisco. His laboratory studies signal transduction in immune and inflammatory responses, with a focus on ubiquitin-dependent signaling and the NF-kB pathways. He has made a number of major contributions to the field, including pioneer work in NF-kB signaling and seminal findings regarding the role of ubiquitination in immune regulation. Dr. Sun was among the first to demonstrate IkB inducible degradation as the fundamental mechanism of NF-kB activation, and his laboratory also pioneered the discovery of the noncanonical NF-kB pathway and demonstration of its regulatory mechanism. Dr. Sun’s laboratory has also made seminal findings regarding how ubiquitination regulates T-cell activation in immune and autoimmune responses. An important part of his ongoing research is to dissect the NF-kB and ubiquitin-dependent signaling pathways in the regulation of T-cell activation and tolerance in animal models of autoimmunity and antitumor immunity.