University of Zurich
Research in Onur Boyman’s laboratory focuses on the modulation of immune responses, with a particular interest in cytokines and cytokine-directed approaches. Boyman and colleagues discovered so-called interleukin-2 (IL-2)/anti-IL-2 antibody complexes and thus opened the field of biased IL-2 immunotherapy. This enables the preferential stimulation of regulatory versus effector T cells for treatment of immunopathologies versus cancer, respectively. Moreover, the Boyman laboratory has studied the role of different anti- and pro-inflammatory cytokines, which led to their recent discovery of a potent regulatory checkpoint in mouse and human neutrophils dependent on cell-intrinsic signaling via the IL-4/IL-13 receptor.